The ImageRegion as contained in the portable SMath with Maxima distribution seems to occasionally loose data.
By whatever reason, the region looses contact to the temporary image file. This happened to me three time just when I tried to save the file. Then I got an error message saying that the file does not exist.
In that case the only chance to keep your image is to make a screenshot, delete the region, create a new one, open in the editor and paste the screenshot.
Unfortunately, I cannot reproduce the precise trigger event for the problem.