The following screenshot has been made after switching the GUI language from german to english in the Tools> Settings dialog
You see misaligned child regions (really big misalignment, not just the usual one seen in "Example Mass m"). Sometimes these re-adjust when pressing re-calculate in the toolbar or sometimes you must start editing the region in order to get back alignment.
When opening the document with the GUI already in english mode, then alignment is as usual.

SMath Studio: SMath Studio Desktop 0.99.7251.32800 portable, 64-bit
OS: Microsoft Windows NT 6.1.7601 Service Pack 1; Windows 7 Professional Service Pack 1, 64-bit
Screen: 1920x1080 px, 96x96 dpi, 96 GP.CDPI
Localization: language=ENG; dec.symbol=<comma>; arg.separator=<semicolon>; OS dec.symbol=<comma>; OS arg.separator=<semicolon>; OS d.g.separator=<period>
Framework: CLR 4.0.30319.42000
installed versions:
v2.0.50727 2.0.50727.5420 SP2
v3.0 3.0.30729.5420 SP2
v3.5 3.5.30729.5420 SP1
v4
Client 4.8.03761
Full 4.8.03761
v4.0
Client 4.0.0.0
Plugins:
- [AppDir] Area Region - 0.99.7251.32800
- [AppDir] HTMLFileType - 1.14.7251.32800
- [AppDir] ImageFileType - 1.11.7251.32800
- [AppDir] Math Region - 0.99.7251.32800
- [AppDir] PictureRegion - 1.10.7251.32800
- [AppDir] PlotRegion - 1.11.7251.32800
- [AppDir] SMath Viewer Files Plugin - 1.1.7251.32841
- [AppDir] SMathFileType - 1.11.7251.32800
- [AppDir] SpecialFunctions - 1.12.7251.32800
- [AppDir] SpecialFunctions - 1.12.7251.32800
- [AppDir] StandardToolboxButtons - 1.1.7251.32800
- [AppDir] TextRegion - 1.11.7251.32800
- [AppDir] XMCDFileType - 1.12.7251.32800
- [UserDir] Conditionally Formatted Label - 1.0.7100.19488
- [UserDir] Custom Functions - 1.1.7200.16172
- [UserDir] Custom Glyphs - 1.1.7200.16176
- [UserDir] Development Tools - 1.0.6974.21980
- [UserDir] DotNumerics - 1.1.7166.24796
- [UserDir] Hyperlink Region - 1.0.7105.20106
- [UserDir] Image Region - 2.99.7100.21996
- [UserDir] Mathcad File Access Functions - 1.0.7243.36103
- [UserDir] MaximaPlugin - 1.98.7100.23756
- [UserDir] Nonlinear Solvers - 1.1.7097.23301
- [UserDir] ODE Solvers - 0.2.7155.3312
- [UserDir] ODE Solvers - 0.2.7155.3312
- [UserDir] PDF Files Plugin - 1.0.7097.27694
- [UserDir] RadioButtonList Region - 1.0.7097.30330
- [UserDir] Slider Region - 1.0.7100.22009
- [UserDir] Snapshot Region - 1.0.7100.22017
- [UserDir] Table Region - 0.2.7097.29803
- [UserDir] Text Region Utilities - 0.4.7200.15920
- [UserDir] Writer Region - 0.22.7200.15900
- [UserDir] X-Y Plot Region (JXCharts) - 0.2.7198.38915
- [UserDir] X-Y Plot Region (JXCharts) - 0.2.7198.38915
- [UserDir] ZedGraph Region (ZedGraph) - 0.1.7264.22538